ABSTRACT
Aim. The aim is to study the correlation between the vaccination rate (VR) and mortality rate of patients with COVID-19 (MpCOV). Methods. The countries with gross domestic product per capita corrected for purchasing power parity (GDP PPP) over $ 10,000 were selected for an ecologic study. The city-states and countries with a population of <1,000,000 were excluded. The number of patients who died from COVID-19 within a week was divided by the number of patients diagnosed with COVID-19 within a week 20 days earlier to calculate MpCOV. Results. We included 85 countries. VR (r = -0.604;p < 0.001) and GDPpcPPP level (r = -0.542;p < 0.001) significantly correlate with MpCOV. Multivariate analysis showed that VR (p = 0.001), rather than GDPpcPPP level (p = 0.202), is an independent determinant of MpCOV. There was no significant difference in MpCOV between groups of countries with VR <20 % and 20-39 % (1.96 [1.21;4.67] vs. 1.96 [1.01;3.36] %;p = 0.464). MpCOV was higher in countries where VR were lower when groups of countries with VR of 20-39 %, 40-59 %, 60-79 %, and ≥80 % were compared (1.96 [1.01;3.36] vs. 1.11 [0.76;1.64] vs. 0.50 [0.39;1.00] vs. 0.16 [0.10;0.21];p = 0.003;p = 0.020, and p = 0.008). Conclusions. An increase in VR correlates with a decrease in MpCOV. © 2022 Russian Journal of Gastroenterology, Hepatology, Coloproctology